Job Opportunities at Inception Therapeutics

Research Scientist or SRA II, Protein Biophysics and Binding Analytics

Inception Therapeutics is seeking a creative, motivated and experienced scientist to join the Protein Therapeutics team in San Diego, California. This position will be key to Inception’s small molecule and biotherapeutic drug discovery programs and will require strong expertise in the theoretical basis and experimental evaluation of molecular interactions and molecular characterization. Two key responsibilities will be the analysis of small and large molecule interactions with various target types, and the elucidation of molecular mechanism for lead molecules. In addition, the scientist in this role will be involved in other Protein Therapeutics group activities, such as protein purification, developability analysis, and protein engineering.

Job Description:

  • Develop and execute methods for the measurement of small and large molecule molecular interactions by SPR and ELISA
  • Design and perform binding experiments for the assessment of lead and reagent binding activity
  • Design and perform experiments for the assessment of biotherapeutics lead developability
  • Perform physicochemical assessments of biomolecule preparations for purity and stability
  • Present results regularly at team meetings
  • Perform diligent and timely notekeeping and work process tracking

Required Qualifications:

  • BS with 6+ years industry experience, or MS with 4+ years industry experience, or PhD + Postdoctoral experience. Industry experience will be in the field of Biotherapeutics
  • A solid understanding of the principles behind protein binding analysis, with a focus on methods for determining binding affinities, kinetics, and thermodynamics
  • Strong expertise in design, execution, and troubleshooting of SPR-based and plate-based binding assays
  • A solid understanding of the principles behind physicochemical properties of proteins and other biomolecules
  • Experience with data analysis and presentation software
  • Excellent written and oral communication skills
  • The individual should be scientifically creative and driven by a willingness to embrace innovation within drug discovery and an eagerness to challenge and meet aggressive timelines
  • The ability to work closely with other group members within teams is essential

Preferred Qualifications:

  • Experience with protein purification and characterization
  • Technical experience in methods of protein analytics, including SDS-PAGE/cGE, analytical SEC, multi-angle light scattering, and charge distribution analysis (cation exchange or electrophoresis)
  • An understanding of the principals and best practices behind biotherapeutic developability would be desirable

Inception Therapeutics is a multi-disciplinary discovery engine partnered with Versant Ventures to build and launch transformative new biopharmaceutical companies. We are home to a dynamic team that enjoys working on cutting-edge science to meet unmet medical need across a variety of therapeutic areas. Our integrated chemistry, biology expertise and capabilities coupled with a successful track record have enabled Inception to become an established leader in new company creation. We offer competitive compensation and excellent benefits packages, as well as working in a supportive team environment. This position is located in our San Diego office. We invite you to consider a career with Inception by submitting your resume to